Other Guidelines

Indian Society for Pediatric and Adolescent Endocrinology

1. Thyroid


a. Newborn Screening Guidelines for Congenital Hypothyroidism in India: Recommendations of the Indian Society for Pediatric and Adolescent Endocrinology (ISPAE) - Part I: Screening and Confirmation of Diagnosis.

Desai MP, Sharma R, Riaz I, Sudhanshu S, Parikh R, Bhatia V.

Indian J Pediatr. 2018 Jun;85(6):440-447. doi: 10.1007/s12098-017-2575-y.


b. Newborn Screening Guidelines for Congenital Hypothyroidism in India: Recommendations of the Indian Society for Pediatric and Adolescent Endocrinology (ISPAE) - Part II: Imaging, Treatment and Follow-up.

Sudhanshu SRiaz ISharma RDesai MPParikh RBhatia V.

Indian J Pediatr. 2018 Jun;85(6):448-453. doi: 10.1007/s12098-017-2576-x. Epub 2018 Feb 17.

c. Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer.

Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S; American Thyroid Association Guidelines Task Force.

Thyroid. 2015 Jul;25(7):716-59. doi: 10.1089/thy.2014.0460.


d. 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis.

Ross DS, Burch HB, Cooper DS, Greenlee MC, Laurberg P, Maia AL, Rivkees SA, Samuels M, Sosa JA, Stan MN, Walter MA

Thyroid. 2016 Oct;26(10):1343-1421.


e. Medullary thyroid cancer: management guidelines of the American Thyroid Association.

American Thyroid Association Guidelines Task Force, Kloos RT, Eng C, Evans DB, Francis GL, Gagel RF, Gharib H, Moley JF, Pacini F, Ringel MD, Schlumberger M, Wells SA Jr.

Thyroid. 2009 Jun;19(6):565-612. doi: 10.1089/thy.2008.0403.


2. Growth


a. Revised IAP growth charts for height, weight and body mass index for 5- to 18-year-old Indian children.*

Indian Academy of Pediatrics Growth Charts Committee, Khadilkar V, Yadav S, Agrawal KK, Tamboli S, Banerjee M, Cherian A, Goyal JP, Khadilkar A, Kumaravel V, Mohan V, Narayanappa D, Ray I, Yewale V.

Indian Pediatr. 2015 Jan;52(1):47-55.

b. Guidelines for Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents: Growth Hormone Deficiency, Idiopathic Short Stature, and Primary Insulin-Like Growth Factor-I Deficiency.

Grimberg A, DiVall SA, Polychronakos C, Allen DB, Cohen LE, Quintos JB, Rossi WC, Feudtner C, Murad MH; Drug and Therapeutics Committee and Ethics Committee of the Pediatric Endocrine Society.

Horm Res Paediatr. 2016;86(6):361-397. doi: 10.1159/000452150. Epub 2016 Nov 25.

c. Diagnosis and management of Silver-Russell syndrome: first international consensus statement.

Wakeling EL, Brioude F, Lokulo-Sodipe O, O'Connell SM, Salem J, Bliek J, Canton AP, Chrzanowska KH, Davies JH, Dias RP, Dubern B, Elbracht M, Giabicani E, Grimberg A, Grønskov K, Hokken-Koelega AC, Jorge AA, Kagami M, Linglart A, Maghnie M, Mohnike K, Monk D, Moore GE, Murray PG, Ogata T, Petit IO, Russo S, Said E, Toumba M, Tümer Z, Binder G, Eggermann T, Harbison MD, Temple IK, Mackay DJ, Netchine I.

Nat Rev Endocrinol. 2017 Feb;13(2):105-124. doi: 10.1038/nrendo.2016.138. Epub 2016 Sep 2.

d. Growth Hormone Research Society workshop summary: consensus guidelines for recombinant human growth hormone therapy in Prader-Willi syndrome.

Deal CL, Tony M, Höybye C, Allen DB, Tauber M, Christiansen JS; 2011 Growth Hormone in Prader-Willi Syndrome Clinical Care Guidelines Workshop Participants.

J Clin Endocrinol Metab. 2013 Jun;98(6):E1072-87. doi: 10.1210/jc.2012-3888. Epub 2013 Mar 29.

e. Recommendations for the diagnosis and management of Prader-Willi syndrome.

Goldstone AP, Holland AJ, Hauffa BP, Hokken-Koelega AC, Tauber M; speakers contributors at the Second Expert Meeting of the Comprehensive Care of Patients with PWS.

J Clin Endocrinol Metab. 2008 Nov;93(11):4183-97. doi: 10.1210/jc.2008-0649. Epub 2008 Aug 12.


f. Use of aromatase inhibitors in children and adolescents with disorders of growth and adolescent development.

Shulman DI, Francis GL, Palmert MR, Eugster EA; Lawson Wilkins Pediatric Endocrine Society Drug and Therapeutics Committee.

Pediatrics. 2008 Apr;121(4):e975-83. doi: 10.1542/peds.2007-2081.

g. Acromegaly: an endocrine society clinical practice guideline.

Katznelson L, Laws ER Jr, Melmed S, Molitch ME, Murad MH, Utz A, Wass JA; Endocrine Society.

J Clin Endocrinol Metab. 2014 Nov;99(11):3933-51. doi: 10.1210/jc.2014-2700. Epub 2014 Oct 30.

h. Clinical practice guideline on diagnosis and treatment of hyponatraemia

Goce Spasovski, Raymond Vanholder, Bruno Allolio, Djillali Annane, Steve Ball, Daniel Bichet, Guy Decaux, Wiebke Fenske, Ewout J Hoorn, Carole Ichai, Michael Joannidis, Alain Soupart, Robert Zietse, Maria Haller, Sabine van der Veer, Wim Van Biesen and Evi Nagler on behalf of the Hyponatraemia Guideline Development Group

Eur J Endocrinol March 1, 2014 170 G1-G47. doi: 10.1530/EJE-13-1020


3. DSD/ Undescended testis


a. Society for Endocrinology UK guidance on the initial evaluation of an infant or an adolescent with a suspected disorder of sex development (Revised 2015).

Ahmed SF, Achermann JC, Arlt W, Balen A, Conway G, Edwards Z, Elford S, Hughes IA, Izatt L, Krone N, Miles H, O'Toole S, Perry L, Sanders C, Simmonds M, Watt A, Willis D.

Clin Endocrinol (Oxf). 2016 May;84(5):771-88. doi: 10.1111/cen.12857.


b. Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline.

Hembree WC, Cohen-Kettenis PT, Gooren L, Hannema SE, Meyer WJ, Murad MH, Rosenthal SM, Safer JD, Tangpricha V, T'Sjoen GG.

J Clin Endocrinol Metab. 2017 Nov 1;102(11):3869-3903. doi: 10.1210/jc.2017-01658. Erratum in: J Clin Endocrinol Metab. 2018 Feb 1;103(2):699.

c. Statement on gender-affirmative approach to care from the pediatric endocrine society special interest group on transgender health.

Lopez X, Marinkovic M, Eimicke T, Rosenthal SM, Olshan JS; Pediatric Endocrine Society Transgender Health Special Interest Group.

Curr Opin Pediatr. 2017 Aug;29(4):475-480. doi: 10.1097/MOP.0000000000000516.


d. Global Disorders of Sex Development Update since 2006: Perceptions, Approach and Care.

Lee PA, Nordenström A, Houk CP, Ahmed SF, Auchus R, Baratz A, Baratz Dalke K, Liao LM, Lin-Su K, Looijenga LH 3rd, Mazur T, Meyer-Bahlburg HF, Mouriquand P, Quigley CA, Sandberg DE, Vilain E, Witchel S; Global DSD Update Consortium.

Horm Res Paediatr. 2016;85(3):158-80. doi: 10.1159/000442975. Epub 2016 Jan 28. Erratum in Horm Res Paediatr. 2016;85(3):180. Koopman, Peter [added].

e. Evaluation and treatment of cryptorchidism: AUA guideline.

Kolon TF, Herndon CD, Baker LA, Baskin LS, Baxter CG, Cheng EY, Diaz M, Lee PA, Seashore CJ, Tasian GE, Barthold JS; American Urological Assocation.

J Urol. 2014 Aug;192(2):337-45. doi: 10.1016/j.juro.2014.05.005.

4. Obesity/ Hypercholesterolemia/ Hypertension

a. Pediatric Obesity-Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline.

Styne DM, Arslanian SA, Connor EL, Farooqi IS, Murad MH, Silverstein JH, Yanovski JA.

J Clin Endocrinol Metab. 2017 Mar 1;102(3):709-757. doi: 10.1210/jc.2016-2573.

b. Drug therapy of high-risk lipid abnormalities in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, with the Council on Cardiovascular Nursing.

Brian W. McCrindle, Elaine M. Urbina, Barbara A. Dennison, Marc S. Jacobson, Julia Steinberger, Albert P. Rocchini, Laura L. Hayman, Stephen R. Daniels

Circulation. 2007;115:1948-1967.

c. Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents; National Heart, Lung, and Blood Institute.

Pediatrics. 2011 Dec;128 Suppl 5:S213-56. doi: 10.1542/peds.2009-2107C. Epub 2011 Nov 14.


d. Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline.

Lenders JW1, Duh QY, Eisenhofer G, Gimenez-Roqueplo AP, Grebe SK, Murad MH, Naruse M, Pacak K, Young WF Jr; Endocrine Society.

 J Clin Endocrinol Metab. 2014 Jun;99(6):1915-42. doi: 10.1210/jc.2014-1498.


e. Screening for Endocrine Hypertension: An Endocrine Society Scientific Statement

William F. Young, David A. Calhoun, Jacques W.M. Lenders, Michael Stowasser, Stephen C. Textor; Endocrine Reviews, Volume 38, Issue 2, 1 April 2017, Pages 103–122,

f. Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents.

Flynn JT, Kaelber DC, Baker-Smith CM, et al; subcommittee on screening and management of high blood pressure in children.

 Pediatrics. 2017 Dec;140(6). pii: e20173035. doi: 10.1542/peds.2017-3035.

g. European Society of Endocrinology Clinical Practice Guideline for long-term follow-up of patients operated on for a phaeochromocytoma or a paraganglioma

P F Plouin, L Amar, O M Dekkers, M Fassnacht, A P Gimenez-Roqueplo, J W M Lenders, C Lussey-Lepoutre, O Steichen and on behalf of the Guideline Working Group

Eur J Endocrinol May 1, 2016 174 G1-G10. doi: 10.1530/EJE-16-0033



a. Insulin resistance in childrenconsensusperspective, and future directions.

Levy-Marchal CArslanian SCutfield WSinaiko ADruet CMarcovecchio MLChiarelli FESPE-LWPES-ISPAD-APPES-APEG-SLEP- JSPEInsulin Resistance in Children Consensus Conference Group.

J Clin Endocrinol Metab. 2010 Dec;95(12):5189-98. doi: 10.1210/jc.2010-1047. Epub 2010 Sep 8.

b. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline.

Legro RS, Arslanian SA, Ehrmann DA, Hoeger KM, Murad MH, Pasquali R, Welt CK; EndocrineSociety.

J Clin Endocrinol Metab. 2013 Dec;98(12):4565-92. doi: 10.1210/jc.2013-2350. Epub 2013 Oct 22.

c. An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence.

Ibáñez L, Oberfield SE, Witchel S, Auchus RJ, Chang RJ, Codner E, Dabadghao P, Darendeliler F, Elbarbary NS, Gambineri A, Garcia Rudaz C, Hoeger KM, López-Bermejo A, Ong K, Peña AS, Reinehr T, Santoro N, Tena-Sempere M, Tao R, Yildiz BO, Alkhayyat H, Deeb A, Joel D, Horikawa R, de Zegher F, Lee PA.

Horm Res Paediatr. 2017;88(6):371-395. doi: 10.1159/000479371. Epub 2017 Nov 13.


d. The Diagnosis and Management of Lipodystrophy Syndromes: A Multi-Society Practice Guideline.

Brown RJAraujo-Vilar DCheung PTDunger DGarg AJack MMungai LOral EAPatni NRother KIvon Schnurbein JSorkina EStanley TVigouroux CWabitsch MWilliams RYorifuji T.

J Clin Endocrinol Metab. 2016 Dec;101(12):4500-4511. Epub 2016 Oct 6.


6. Hypoglycemia


a. Recommendations from the Pediatric Endocrine Society for Evaluation and Management of Persistent Hypoglycemia in Neonates, Infants, and Children.

Thornton PS, Stanley CA, De Leon DD, Harris D, Haymond MW, Hussain K, Levitsky LL, Murad MH, Rozance PJ, Simmons RA, Sperling MA, Weinstein DA, White NH, Wolfsdorf JI; Pediatric Endocrine Society.

J Pediatr. 2015 Aug;167(2):238-45. doi: 10.1016/j.jpeds.2015.03.057.


b. Clinical practice guidelines for congenital hyperinsulinism

Tohru Yorifuji, Reiko Horikawa, Tomonobu Hasegawa, Masanori Adachi, Shun Soneda, Masanori Minagawa, Shinobu Ida, Takeo Yonekura, Yoshiaki Kinoshita, Yutaka Kanamori, Hiroaki Kitagawa, Masato Shinkai, Hideyuki Sasaki, Masaki Nio, (on behalf of The Japanese Society for Pediatric Endocrinology and The Japanese Society of Pediatric Surgeons)

Clin Pediatr Endocrinol. 2017; 26(3): 127–152.


7. Bone


a. Informing evidence-based clinical practice guidelines for children with cerebral palsy at risk of osteoporosis: an update.

Ozel S, Switzer L, Macintosh A, Fehlings D.

Dev Med Child Neurol. 2016 Sep;58(9):918-23. doi: 10.1111/dmcn.13196.


b. Alison M. Boyce, Rachel I. Gafni; Approach to the Child with Fractures, The Journal of Clinical Endocrinology & Metabolism, Volume 96, Issue 7, 1 July 2011, Pages 1943–1952,

c. Global Consensus Recommendations on Prevention and Management of Nutritional Rickets.

Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, Michigami T, Tiosano D, Mughal MZ, Mäkitie O, Ramos-Abad L, Ward L, DiMeglio LA, Atapattu N, Cassinelli H, Braegger C, Pettifor JM, Seth A, Idris HW, Bhatia V, Fu J, Goldberg G, Sävendahl L, Khadgawat R, Pludowski P, Maddock J, Hyppönen E, Oduwole A, Frew E, Aguiar M, Tulchinsky T, Butler G, Högler W.

J Clin Endocrinol Metab. 2016 Feb;101(2):394-415. doi: 10.1210/jc.2015-2175.


d. Consensus guidelines on the use of bisphosphonate therapy in children and adolescents.

Simm PJ, Biggin A, Zacharin MR, Rodda CP, Tham E, Siafarikas A, Jefferies C, Hofman PL, Jensen DE, Woodhead H, Brown J, Wheeler BJ, Brookes D, Lafferty A, Munns CF; APEG Bone Mineral Working Group.J Paediatr Child Health. 2018 Mar;54(3):223-233. doi: 10.1111/jpc.13768.

e. Dual-energy X-ray absorptiometry interpretation and reporting in children and adolescents: the revised 2013 ISCD Pediatric Official Positions.


Crabtree NJ, Arabi A, Bachrach LK, Fewtrell M, El-Hajj Fuleihan G, Kecskemethy HH, Jaworski M, Gordon CM; International Society for Clinical Densitometry.

J Clin Densitom. 2014 Apr-Jun;17(2):225-42. doi: 10.1016/j.jocd.2014.01.003.


e. Bone health in children and adolescents with chronic diseases that may affect the skeleton: the 2013 ISCD Pediatric Official Positions.

Bianchi ML, Leonard MB, Bechtold S, Högler W, Mughal MZ, Schönau E, Sylvester FA, Vogiatzi M, van den Heuvel-Eibrink MM, Ward L; International Society for Clinical Densitometry.

J Clin Densitom. 2014 Apr-Jun;17(2):281-94. doi: 10.1016/j.jocd.2014.01.005.


8. Pituitary

a. Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline.

Melmed S, Casanueva FF, Hoffman AR, Kleinberg DL, Montori VM, Schlechte JA, Wass JA; Endocrine Society.

J Clin Endocrinol Metab. 2011 Feb;96(2):273-88. doi: 10.1210/jc.2010-1692.

b. Craniopharyngioma.

Müller HL

Endocr Rev. 2014 Jun;35(3):513-43. doi: 10.1210/er.2013-1115. Epub 2014 Jan 27.


9. Adrenal

a. Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline.

Speiser PW, Azziz R, Baskin LS, Ghizzoni L, Hensle TW, Merke DP, Meyer-Bahlburg HF, Miller WL, Montori VM, Oberfield SE, Ritzen M, White PC; Endocrine Society.

J Clin Endocrinol Metab. 2010 Sep;95(9):4133-60. doi: 10.1210/jc.2009-2631. Erratum in: J Clin Endocrinol Metab. 2010 Nov;95(11):5137.

b. Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline.

Bornstein SR, Allolio B, Arlt W, Barthel A, Don-Wauchope A, Hammer GD, Husebye ES, Merke DP, Murad MH, Stratakis CA, Torpy DJ

J Clin Endocrinol Metab. 2016 Feb;101(2):364-89. doi: 10.1210/jc.2015-1710. Epub 2016 Jan 13.

c. Treatment of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline.

Nieman LK, Biller BM, Findling JW, Murad MH, Newell-Price J, Savage MO, Tabarin A; Endocrine Society.

J Clin Endocrinol Metab. 2015 Aug;100(8):2807-31. doi: 10.1210/jc.2015-1818. Epub 2015 Jul 29.

d. Cushing's syndrome: a practical approach to diagnosis and differential diagnoses.

Pappachan JM, Hariman C, Edavalath M, Waldron J, Hanna FW.

J Clin Pathol. 2017 Apr;70(4):350-359. doi: 10.1136/jclinpath-2016-203933. Epub 2017 Jan 9

e. Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline in collaboration with the European Network for the Study of Adrenal Tumors.

Fassnacht M, Arlt W, Bancos I, Dralle H, Newell-Price J, Sahdev A, Tabarin A, Terzolo M, Tsagarakis S, Dekkers OM.

Eur J Endocrinol. 2016 Aug;175(2):G1-G34. doi: 10.1530/EJE-16-0467.


f. The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline.

Nieman LK, Biller BM, Findling JW, Newell-Price J, Savage MO, Stewart PM, Montori VM.

J Clin Endocrinol Metab. 2008 May;93(5):1526-40. doi: 10.1210/jc.2008-0125. Epub 2008 Mar 11.


10. Puberty

a. Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting.

Gravholt CHAndersen NHConway GSDekkers OMGeffner MEKlein KOLin AEMauras NQuigley CARubin KSandberg DESas TCJSilberbach MSöderström-Anttila VStochholm Kvan Alfen-van derVelden JAWoelfle JBackeljauw PFInternational Turner Syndrome Consensus Group.

Eur J Endocrinol. 2017 Sep;177(3):G1-G70. doi: 10.1530/EJE-17-0430.

b. Consensus statement on the use of gonadotropin-releasing hormone analogs in children.

Carel JC, Eugster EA, Rogol A, Ghizzoni L, Palmert MR; ESPE-LWPES GnRH Analogs Consensus Conference Group, Antoniazzi F, Berenbaum S, Bourguignon JP, Chrousos GP, Coste J, Deal S, de Vries L, Foster C, Heger S, Holland J, Jahnukainen K, Juul A, Kaplowitz P, Lahlou N, Lee MM, Lee P, Merke DP, Neely EK, Oostdijk W, Phillip M, Rosenfield RL, Shulman D, Styne D, Tauber M, Wit JM.

Pediatrics. 2009 Apr;123(4):e752-62. doi: 10.1542/peds.2008-1783. Epub 2009 Mar 30.

11. Cancer, Thalassemia


a. Long-term follow up guidelines for survivors of caner (Children Oncology group 2013)

b. Late Effects of Treatments for Childhood Cancer (NIH-National Cancer Institute)


c. Rajesh V. Thakker, Paul J. Newey, Gerard V. Walls, John Bilezikian, Henning Dralle, Peter R. Ebeling, Shlomo Melmed, Akihiro Sakurai, Francesco Tonelli, Maria Luisa Brandi; Clinical Practice Guidelines for Multiple Endocrine Neoplasia Type 1 (MEN1), The Journal of Clinical Endocrinology & Metabolism, Volume 97, Issue 9, 1 September 2012, Pages 2990–3011,

d. Cappellini MD, Cohen A, Porter J, Taher A, Viprakasit V.Guidelines for the Management of Transfusion Dependent Thalassaemia (TDT) [Internet], 3rd Edition , Thalassaemia International Federation; 2014; 48. (Chapter 8 Endocrine Diseases)


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